Clinical Outcomes for Single Stent and Multiple Stents in Contemporary Practice

AbstractBackgroundStents had been demonstrated to be safe and effective in the treatment of severe coronary artery disease (CAD); however, the current knowledge on percutaneous coronary intervention (PCI) in treating patients requiring 2 or more stents placements is still limited.HypothesisPatients who required 2 or more stents might have worse clinical outcomes.MethodsA total of 2371 patients who underwent stenting were divided into a single stenting group (n = 1233) and a multiple stenting group (n = 1138). We assessed the cumulative incidence of major adverse cardiac events (death, acute myocardial infarction, and target‐vessel revascularization) and stent thrombosis during 1‐year follow‐up.ResultsThe 1‐year unadjusted cumulative incidence of major adverse cardiac events was 7.7% in the multiple stenting group and 5.4% in the single stenting group (P = 0.02 by log‐rank test). After adjustment, there was a trend toward a lower rate of 1‐year major adverse cardiac events in the single stenting group than in the multiple stenting group (P = 0.09). A nonsignificant trend was also detected in favor of the single stenting group, as compared with the multiple stenting group, at the rate of acute myocardial infarction (1.3% vs 1.7%, P = 0.89) and at the rate of target‐vessel revascularization (4.5% vs 5.4%, P = 0.08).ConclusionsAlthough the use of a single stent in coronary artery disease has less incidence of adverse cardiac events at 1 year as compared with the use of multiple stents, the difference was not statistically significant. Copyright © 2009 Wiley Periodicals, Inc.