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Observation of Angiogenesis in Granulation Tissue Using the Dressing Material

Aim: It is important to analyze the angiogenesis and the formation of the granulation tissue in understanding the wound healing process. The dressing material is thought that the wound healing is promoted, and understanding the effect of the dressing material. The model which used the dressing material was made, and the angiogenesis in the granulation tissue formation process were compared. Method: The Sprague‐Dawrey rat's granulation formation model and the model which used the dressing materials were made. The granulation tissue was removed on the 7th day, the 14th day, the 28th day, and the 42nd day. The angiogenesis and the formation of network of newly formed vessels during the granulation tissue formation were observed with Confocal laser scanning microscopy. Result: The angiogenesis starts from the depths part of the granuration tissue. Afterwards, it progresses superficial part of the granulation tissue, and the network of the blood vessel is formed. In this process, as the model which used the dressing material, the network of the angiogenesis was admitted from early time.