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Genetic background of esophageal squamous cell carcinoma
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A nyelőcsőrák a kilencedik leggyakoribb rosszindulatú daganat. Több mint 90%-ban előrehaladott állapotban kerül felismerésre. A sebészi beavatkozás, a kemo-, illetve radioterápia lehetőségei korlátozottak. Napjainkban a génterápia került az érdeklődés előterébe. A szerzők a nyelőcsőlaphámrák genetikai és molekuláris hátterét és a génterápiával elért kezdeti tapasztalatokat tekintik át. Ismertetik a komplementer nukleinsavak (antisense terápia), a génpótlás, a kis interferáló RNS-k alkalmazásának lehetőségeit.
Title: Genetic background of esophageal squamous cell carcinoma
Description:
A nyelőcsőrák a kilencedik leggyakoribb rosszindulatú daganat.
Több mint 90%-ban előrehaladott állapotban kerül felismerésre.
A sebészi beavatkozás, a kemo-, illetve radioterápia lehetőségei korlátozottak.
Napjainkban a génterápia került az érdeklődés előterébe.
A szerzők a nyelőcsőlaphámrák genetikai és molekuláris hátterét és a génterápiával elért kezdeti tapasztalatokat tekintik át.
Ismertetik a komplementer nukleinsavak (antisense terápia), a génpótlás, a kis interferáló RNS-k alkalmazásának lehetőségeit.
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