Development and Evaluation of Eplerenone Microbeads as Floating Drug Delivery System using Design of Experiment

The present study was designed to formulate floating microbeads of eplerenone for decreasing dosing frequency and increasing gastric residence. The floating properties of the gastric juice were used to control the stomach stay time. Eplerenone was selected as a model bioactive which is used in lowering blood pressure by loading into floating microspheres was designed by using polymer ethyl cellulose and solvent ratio (Dichloromethane: methanol), keeping. The floating microbeads were studied for their drug entrapment efficiency, shape, percentage yield, and particle size, surface morphology, in-vitro drug release studies, percentage buoyancy, and formulation stability studies. Dichloromethane we used (DCM) as a constant and stirred them for hours. The study showed that fluid evaporation can be used to make floating microbeads that contain eplerenone. This method can be used to successfully make eplerenone-loaded floating microbeads. The study showed that making floating eplerenone microbeads with controlled release is a good way to cut down on how often you have to take your medicine.