The Effect of Gastric Botox on Body Weight Loss: A Clinical Experience

Abstract Backround/Aims: This retrospective cross-sectional study aimed to evaluate the efficacy of gastric botulinum toxin A (BTX-A) injection in the treatment of obesity. Anthropometric changes, diet adaptation, Early feelings of satiety, and constipation status were analyzed in the injected patients during a sixteen-week period. Materials and Methods A sample of this study consists of 31 female patients who received BTX-A injections between January and March 2023. Patients' information was accessed from patient follow-up files. The file includes sociodemographic information, anthropometric measurements, dietary adaptation data measured by visual analog score, and data on satiety and constipation. A diet containing 1000 calories of 40% carbohydrates, 25% protein, and 35% fat was given to the patients by the dietitian. The results were calculated with the SPSS 22.0 program and interpreted at a 95% confidence level. Results 500 U BTX-A injection was effective in reducing body weight, BMI, fat mass and fat percentages. There was a loss of 5.12 kg in body weight and a decrease of 1.8 points in BMI. An important part of weight loss in the body is adipose tissue. There was no significant loss of fat-free mass. Diet adaptation and early satiety were less in the sixteenth week than in the first weeks. Conclusion BTX-A injection is effective in losing body weight, BMI, and fat mass together with diet therapy. It is thought that it can be applied in the treatment of obesity together with diet in patients who are suitable for injection. btx-a injection also increases the diet compliance of patients who do not comply with the diet.