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Water‐dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent
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Abstract
Gadolinium oxide (Gd
2
O
3
) nanoplates have been successfully synthesized by thermal decomposition method in the presence of oleic acid and oleylamine as surfactants. As a result, the nanoplates have average edge length and thickness around 10 nm and 1.1 nm, respectively. The hydrophobic OA/OM capped Gd
2
O
3
nanoplates were encapsulated with amphiphilic poly (maleic anhydride‐alt‐1‐octadecene) polymer (PMAO) for phase transfer into aqueous media. The obtained Gd
2
O
3
@PMAO showed a hydrodynamic size of 32 nm with good dispersion in water solvent and stable in wide range of pH (pH=2÷11) and at electrolyte concentrations as high as NaCl 380 mM. In addition, the in vitro toxicity tests confirmed the biocompatibility of Gd
2
O
3
@PMAO nanoplates. The magnetic resonance imaging (MRI) result exhibited the r
1
of Gd
2
O
3
@PMAO nanoplates (16.95 mM
−1
s
−1
) is four times higher than that of clinically used Gd‐DTPA. These results suggest that the PMAO coated ‐Gd
2
O
3
nanoplates are potential T
1
contrast agents for in vivo MRI application.
Title: Water‐dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent
Description:
Abstract
Gadolinium oxide (Gd
2
O
3
) nanoplates have been successfully synthesized by thermal decomposition method in the presence of oleic acid and oleylamine as surfactants.
As a result, the nanoplates have average edge length and thickness around 10 nm and 1.
1 nm, respectively.
The hydrophobic OA/OM capped Gd
2
O
3
nanoplates were encapsulated with amphiphilic poly (maleic anhydride‐alt‐1‐octadecene) polymer (PMAO) for phase transfer into aqueous media.
The obtained Gd
2
O
3
@PMAO showed a hydrodynamic size of 32 nm with good dispersion in water solvent and stable in wide range of pH (pH=2÷11) and at electrolyte concentrations as high as NaCl 380 mM.
In addition, the in vitro toxicity tests confirmed the biocompatibility of Gd
2
O
3
@PMAO nanoplates.
The magnetic resonance imaging (MRI) result exhibited the r
1
of Gd
2
O
3
@PMAO nanoplates (16.
95 mM
−1
s
−1
) is four times higher than that of clinically used Gd‐DTPA.
These results suggest that the PMAO coated ‐Gd
2
O
3
nanoplates are potential T
1
contrast agents for in vivo MRI application.
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