A STUDY ON CLINICOPATHOLOGICAL PROFILE OF ORAL SUBMUCOUS FIBROSIS

Background: Oral submucous brosis is a leading cause of oral cancer. So it is necessary to study its clinicopathological prole for the early diagnosis and prompt treatment. To assess the clinical prole and to eval Objectives: uate the histological prole of oral submucous brosis. Materials and Methods: A cross-sectional observational study conducted in the Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, Manipur, India for a period of 2 years from September 2018 to August 2020. 78 oral submucous brosis patients were enrolled for the study. Clinical features, different habits and histopathological features were studied. Majority of the patients were in the Results: age group 21-30 years with male to female ratio of 1:1.36. Gutkha/talab was the most common habit among the study population. The mean duration of habits was 5.51 years with a minimum duration of 2 years and maximum duration of 15years. Majority of the patients (65.4%) had duration of habits of 1-5 years. Most of the patients (65.4%) clinically presented with difculty in opening of mouth. Fibrosis was most commonly seen in buccal mucosa and palate. Most of the patients were in clinical stage II (57.7%) and in histopathological grade II (60.3%). There was no statistically signicant correlation found between clinical staging and histopathological grading (P value – 0.627) Gutkha/talab is Conclusion: more responsible for the development of oral submucous brosis. Early diagnosis and treatment is important to prevent the progression to oral cancer.