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Combinatorial Chemistry

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AbstractThe article contains sections titled:1.Introduction2.Concept of Combinatorial Chemistry3.Methods and Techniques of Combinatorial Synthesis3.1.Synthetic Strategies Towards Combinatorial Libraries3.1.1.Split ‐ Pool Synthesis Towards Combinatorial Libraries3.1.1.1.Techniques using Resin Beads3.1.1.2.Tea‐Bag Method3.1.2.Parallel Synthesis Towards Combinatorial Libraries3.1.2.1.Reaction Apparatus using Resin Beads3.1.2.2.Multipin Technique3.1.2.3.Spatially Addressable Parallel Synthesis on Silica Wafer3.1.3.Reagent Mixture Synthesis Towards Combinatorial Libraries3.2.Synthetic Methodology for Organic Library Construction3.2.1.Solid‐Phase Organic Synthesis3.2.1.1.Solid Support, Linker, and Cleavage Strategies3.2.1.2.Reaction Portfolio3.2.2.Synthesis in Solution and Liquid‐Phase Synthesis4.Characterization of Combinatorial Libraries4.1.Analytical Characterization4.2.Hit Identification in Combinatorial Libraries by High‐Throughput Screening4.2.1.Strategies for Libraries of Compound Mixtures4.2.1.1.On‐Bead Screening4.2.1.2.Deconvolution4.2.1.2.1.Iterative Deconvolution4.2.1.2.2.Deconvolution by Positional Scanning4.2.1.2.3.Deconvolution by Orthogonal Libraries4.2.1.3.Encoding4.2.1.4.Multiple Cleavable Linkers4.2.2.Strategies for Libraries of Separate Single Compounds4.2.3.Conclusion5.Automation and Data Processing5.1.Synthesis Automation and Data Processing5.2.Automated Purification6.Library Design and Diversity Assessment6.1.Diversity Assessment for Selection of Building Blocks or Compound6.2.Iterative Optimization Methods7.Economic Aspects and Industrial Case Studies8.Further Developments8.1.Combinatorial Chemistry and Catalysis8.2.Combinatorial Chemistry and Material Science
Wiley
Dominika Tiebes Stefan Peters
Ullmann's Encyclopedia of Industrial Chemistry
2006
Title: Combinatorial Chemistry
Description:
AbstractThe article contains sections titled:1.
Introduction2.
Concept of Combinatorial Chemistry3.
Methods and Techniques of Combinatorial Synthesis3.
1.
Synthetic Strategies Towards Combinatorial Libraries3.
1.
1.
Split ‐ Pool Synthesis Towards Combinatorial Libraries3.
1.
1.
1.
Techniques using Resin Beads3.
1.
1.
2.
Tea‐Bag Method3.
1.
2.
Parallel Synthesis Towards Combinatorial Libraries3.
1.
2.
1.
Reaction Apparatus using Resin Beads3.
1.
2.
2.
Multipin Technique3.
1.
2.
3.
Spatially Addressable Parallel Synthesis on Silica Wafer3.
1.
3.
Reagent Mixture Synthesis Towards Combinatorial Libraries3.
2.
Synthetic Methodology for Organic Library Construction3.
2.
1.
Solid‐Phase Organic Synthesis3.
2.
1.
1.
Solid Support, Linker, and Cleavage Strategies3.
2.
1.
2.
Reaction Portfolio3.
2.
2.
Synthesis in Solution and Liquid‐Phase Synthesis4.
Characterization of Combinatorial Libraries4.
1.
Analytical Characterization4.
2.
Hit Identification in Combinatorial Libraries by High‐Throughput Screening4.
2.
1.
Strategies for Libraries of Compound Mixtures4.
2.
1.
1.
On‐Bead Screening4.
2.
1.
2.
Deconvolution4.
2.
1.
2.
1.
Iterative Deconvolution4.
2.
1.
2.
2.
Deconvolution by Positional Scanning4.
2.
1.
2.
3.
Deconvolution by Orthogonal Libraries4.
2.
1.
3.
Encoding4.
2.
1.
4.
Multiple Cleavable Linkers4.
2.
2.
Strategies for Libraries of Separate Single Compounds4.
2.
3.
Conclusion5.
Automation and Data Processing5.
1.
Synthesis Automation and Data Processing5.
2.
Automated Purification6.
Library Design and Diversity Assessment6.
1.
Diversity Assessment for Selection of Building Blocks or Compound6.
2.
Iterative Optimization Methods7.
Economic Aspects and Industrial Case Studies8.
Further Developments8.
1.
Combinatorial Chemistry and Catalysis8.
2.
Combinatorial Chemistry and Material Science.
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