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Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer

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Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49–57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively), lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L) and C-reactive protein (p = 0.01, 0.0–0.01 mg/L). It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL). Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine). Taken together, our pilot study provides the first evidence that the potential biomarker of PCa—sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA.
Title: Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
Description:
Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine.
Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49–57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling.
It was found that bicycle riding resulted in elevated serum uric acid (p = 0.
001, median 271.
76 vs.
308.
44 µmol/L pre- and post-ride, respectively), lactate (p = 0.
01, median 2.
98 vs.
4.
8 mmol/L) and C-reactive protein (p = 0.
01, 0.
0–0.
01 mg/L).
It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate.
The subjects exhibited either significantly higher post-ride tPSA (p = 0.
002, median 0.
69 vs.
1.
1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.
028, median 0.
25 vs.
0.
35 ng/mL).
Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.
20, median 1.
64 vs.
1.
92 µmol/mL for serum sarcosine, and p = 0.
15, median 0.
02 µmol/mmol of creatinine vs.
0.
01 µmol/mmol of creatinine for urinary sarcosine).
Taken together, our pilot study provides the first evidence that the potential biomarker of PCa—sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA.

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