EPID-21. EPIDEMIOLOGY AND CLINICOPATHOLOGICAL FEATURES OF MENINGIOMA PATIENTS: FINDINGS FROM NATIONAL BRAIN CENTER HOSPITAL INDONESIA

Abstract BACKGROUNDS Meningioma is considered as one of high prevalence disease, eight cases per 100.000 population, among intracranial tumours. This study aimed to assess the epidemiology and clinicopathological features of meningioma patients. METHODS This is a retrospective cohort study of hospitalized meningioma patients, excluding spinal meningioma, in National Brain Hospital, Jakarta, Indonesia between 2020 and 2022. Patient’s characteristics, symptoms, MRI results before surgery, and MRI results after surgery were obtained from medical records. Chi-square test, Fisher’s exact test, and logistic regression analysis performed with p-value < 0.05 was considered as significant. RESULTS We analysed 325 patients between 2020 and 2022, which number increases per year. Meningioma grade I was predominant than grade II and III, however grade II and III patients were slightly older than grade I patients (mean age 47.6 ± SD 13.7 years and 46.9 ± 10.3 years, respectively). The majority of patients were females than males with 4 to 1 ratio. The most common locations of brain meningioma were convexity (26.8%), followed by parasellar (11.7%), and falx (34%). Preoperative clinical symptoms in the form of muscle weakness (p=0.04), vision problem (p=0.02), hearing impairment (p=0.006), slusrred speech (p=0.003), and ptosis (0.01) were significantly related to more severe meningioma grading. However, in multivariable logistic regression only hearing impairment was significantly related with meningioma grading with odds ratio 0.313 (95% CI 0.113-0.869, p=0.02). CONCLUSIONS Meningioma prevalence alarming rise should get more attention. Especially as this tumor usually occurs productive age population. Clinical symptoms are associated with the severity, however further study is needed to support our finding.