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Genomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republic
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ABSTRACT
A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing
Escherichia coli
sequence type 38 (ST38) in the city of Brno. Forty-two ST38
E. coli
isolates harbored the
bla
NDM-5
gene on the chromosome. Virulence factors confirmed the persistence of these isolates through biofilm formation. Single Nucleotide Polymorphisms (SNPs)-based phylogeny and CRISPR assay typing showed minimal genomic variations, implying a clonally driven outbreak. Results suggest that this high-risk clone may impose a nationwide problem.
American Society for Microbiology
Katerina Chudejova
Tsolaire Sourenian
Jana Palkovicova
Katarina Stredanska
Lucie Nechutna
Katerina Vlkova
Vendula Studentova
Jaroslav Hrabak
Costas C. Papagiannitsis
Monika Dolejska
Ibrahim Bitar
Marian Glasnak
Dana Krckova
Beata Horvathova
Jana Jurankova
Renata Tejkalova
Zora Pokorna
Vladimir Fibiger
David Sus
Marian Mednansky
Lenka Ryskova
Miriam Koupilova
Jana Kotalikova
Miroslava Prejzkova
Marie Bohackova
Marie Smolikova
Helena Skacan
Denisa Vesela
Blanka Puchalkova
Galina Eliasova
Helena Nedvedova
Lenka Unuckova
Yvona Barinkova
Hana Kremeckova
Daniela Fackova
Jana Janeckova
Roman Jirsa
Roman Zaruba
Eva Vesela
Dana Zamazalova
Marie Dovalova
Iva Vagnerova
Vladimir Kurfurst
Blanka Ochvatova
Eva Chmelarova
Eva Krejci
Eva Zalabska
Vera Kurkova
Simona Blahova
Tamara Bergerova
Vaclava Adamkova
Jan Kubele
Marketa Skruzna
Daniela Balikova
Alena Steinerova
Zuzana Semerakova
Miloslava Kocianova
Martina Curdova
Helena Zemlickova
Vladislav Jakubu
Zuzana Kadleckova
Elka Nycova
Helena Jordakova
Otakar Nyc
Filip Prusik
Ivana Kohnova
Renata Holnova
Eva Simeckova
Erika Czyzova
Alice Kucharova
Ladislav Trojan
Danuta Urbusova
Eva Vitova
Jana Repiscakova
Jarmila Miklova
Lenka Dvorakova
Jirina Jiresova
Jan Tkadlec
Zdena Pitakova
Natasa Bartonikova
Michal Stanek
Title: Genomic characterization of ST38 NDM-5-producing
Escherichia coli
isolates from an outbreak in the Czech Republic
Description:
ABSTRACT
A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing
Escherichia coli
sequence type 38 (ST38) in the city of Brno.
Forty-two ST38
E.
coli
isolates harbored the
bla
NDM-5
gene on the chromosome.
Virulence factors confirmed the persistence of these isolates through biofilm formation.
Single Nucleotide Polymorphisms (SNPs)-based phylogeny and CRISPR assay typing showed minimal genomic variations, implying a clonally driven outbreak.
Results suggest that this high-risk clone may impose a nationwide problem.
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