Oral Flurbiprofen Spray for Posttonsillectomy Pain

ObjectiveTonsillectomy is still one of the most common surgical procedures, but there exists no standard guideline for pain management after tonsillectomy. Our aim is to determine whether oral spray of flurbiprofen reduces pain and has an influence on other morbid outcomes following tonsillectomy.Study DesignProspective, double‐blind, randomized, placebo controlled.SettingPatients at Ataturk Training and Research Hospital, Ankara, Turkey.Subjects and MethodsThis study was performed on 84 patients (45 in flurbiprofen group, 39 in placebo group) who underwent tonsillectomy. The patients were randomly chosen, and each used oral spray of flurbiprofen 3 times daily or placebo solution at the same regimen. Efficacy was assessed by changes in Numeric Pain Rating Scale. Data were collected at postoperative days 1, 3, 5, and 7 for pain, bleeding, and healing. Data for Mallampati scores were also collected.ResultsThere were no significant difference between groups with respect to the demographic data. The flurbiprofen group had statistically significant lower pain scores at days 1, 3, 5, and 7 (P =. 000, P =. 002, P =. 001, P =. 000, respectively). On days 3 and 7, pain scores were significantly different between different Mallampati groups (P =. 049, P =. 015, respectively). The flurbiprofen group required less analgesic than the placebo group during the study period on days 1, 3, 5, and 7 (P =. 001, P =. 001, P =. 03, P =. 001, respectively). Healing and side effects were not significantly different between the groups.ConclusionIn this study, topical use of flurbiprofen may reduce posttonsillectomy pain without any evidence of additional complications.