Investigating the efficacy of dipotassium glycyrrhizin emollients in adult atopic dermatitis: A focused randomized parallel-controlled clinical study

Background & Objective: Atopic dermatitis (AD), a chronic inflammatory skin condition, is primarily characterized by persistent itching and significant sleep disruption. Dipotassium glycyrrhizin, known for its anti-inflammatory properties, has shown potential in AD treatment. This study aims to evaluate the effectiveness of emollients containing dipotassium glycyrrhiza extract and the impact of varying application methods on improving the clinical severity of atopic dermatitis in adults during remission periods. Methods: systemic emollient, topical emollient, or no emollient, for an eight weeks duration. The study compared the incidence, disease assessment, and occurrence of adverse events across these groups. Results: After 12 weeks, the SCORAD score in the systemic emollient group decreased significantly by 6.56 points, more than the 4.03-point reduction in the topical emollient group (p < 0.05). The NRS itching score also showed notable decreases in both emollient groups compared to the no-emollient group (p < 0.05). The complete response rate was significantly higher in the emollient-treated groups than in the non-emollient group (p < 0.05). Conclusion: Regular use of dipotassium glycyrrhizin-containing emollients in adults with mild to moderate AD can effectively reduce symptoms and frequency of flare-ups, without notable adverse effects. doi: https://doi.org/10.12669/pjms.41.7.9559 How to cite this: Xia J, Liu X, Wang Z, Zhang Y, Jiang G. Investigating the efficacy of dipotassium glycyrrhizin emollients in adult atopic dermatitis: A focused randomized parallel-controlled clinical study. Pak J Med Sci. 2025;41(7):1937-1942. doi: https://doi.org/10.12669/pjms.41.7.9559 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.