Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Compositional Flexibility of the ER-Mitochondria Encounter Structure
View through CrossRef
Abstract
Yeast mitochondria receive the majority of their lipids from the endoplasmic reticulum (ER) via the heterotetrameric ERMES lipid transport complex. This complex is thought to establish a lipid transporting tube of fixed composition spanning the space between both organelles. Intriguingly, however, some of the lipid-transporting components of the complex can be replaced by an artificial ER-mitochondria tether without lipid transport activity, indicating that ERMES subunits are not all of equal importance for lipid transport. Here, we propose a model whereby lipid transfer by the ERMES complex can occur with various sub-ensembles of ERMES, and minimally with only one of the four members, namely Mmm1. Our results imply flexibility in the composition of the ERMES complex, which might help it accommodate various interorganelle distances.
Title: Compositional Flexibility of the ER-Mitochondria Encounter Structure
Description:
Abstract
Yeast mitochondria receive the majority of their lipids from the endoplasmic reticulum (ER) via the heterotetrameric ERMES lipid transport complex.
This complex is thought to establish a lipid transporting tube of fixed composition spanning the space between both organelles.
Intriguingly, however, some of the lipid-transporting components of the complex can be replaced by an artificial ER-mitochondria tether without lipid transport activity, indicating that ERMES subunits are not all of equal importance for lipid transport.
Here, we propose a model whereby lipid transfer by the ERMES complex can occur with various sub-ensembles of ERMES, and minimally with only one of the four members, namely Mmm1.
Our results imply flexibility in the composition of the ERMES complex, which might help it accommodate various interorganelle distances.
Related Results
Effect of mitochondrial circulation on mitochondrial age density distribution
Effect of mitochondrial circulation on mitochondrial age density distribution
Abstract
Recent publications report that although the mitochondria population in an axon can be quickly replaced by a combination of retrograde and anterograde axon...
Compositional Space Parameterization for Flow Simulation
Compositional Space Parameterization for Flow Simulation
Abstract
Thermodynamic equilibrium (flash) calculations in compositional simulators are used to find the partitioning of components among fluid phases. The basic ...
P-791 Supplementation of mitochondria from endometrial mesenchymal stem cells (EnMSCs) improves oocyte quality in aged mice
P-791 Supplementation of mitochondria from endometrial mesenchymal stem cells (EnMSCs) improves oocyte quality in aged mice
Abstract
Study question
To improve the quality of aging oocytes by supplementing the mitochondria from endometrial mesenchymal s...
Healthy Mitochondria: The Brake of Cell Proliferation of Malignant Melanoma
Healthy Mitochondria: The Brake of Cell Proliferation of Malignant Melanoma
Abstract
Background: Melanoma has become the leading cause of death from skin disease, and male patients show higher mortality rate than female. Mitochondrial transplantati...
Meiotic purification of dysfunctional mitochondria in mouse oocytes
Meiotic purification of dysfunctional mitochondria in mouse oocytes
Abstract
Mitochondrial purification, including mitophagy, during oogenesis is critical for ensuring accurate mitochondrial DNA transmission, but it remains unclea...
MITOCHONDRIA MORPHOLOGY AND THE ROLE OF PDE2 IN CARDIAC PATHOPHYSIOLOGY
MITOCHONDRIA MORPHOLOGY AND THE ROLE OF PDE2 IN CARDIAC PATHOPHYSIOLOGY
Mitochondria possess a highly dynamic morphology which can change to meet metabolic demands. Altered mitochondria morphology has been reported in a number of heart conditions where...
The complexities of investigating mitochondria dynamics in multiple sclerosis and mouse models of MS
The complexities of investigating mitochondria dynamics in multiple sclerosis and mouse models of MS
Multiple sclerosis (MS) is a demyelinating, degenerating disorder of the central nervous system (CNS) that is accompanied by mitochondria energy production failure. A loss of myeli...
Mitochondria transfer enhances bone marrow mesenchymal stem cell functions and promotes bone defect healing
Mitochondria transfer enhances bone marrow mesenchymal stem cell functions and promotes bone defect healing
Abstract
Background: Bone marrow-derived mesenchymal stem cells (BMSCs) transplantation is considered a promising therapeutic approach for bone defect repair. However, duri...