Evaluation of the Effect of Anacardium Occidentale Cashew Apple Juice on Kidney of Gentamicin Induced Injury in Albino Rats

Background and Objective: With worldwide research in ethnopharmacology, some herbal medicines have been translated into modern remedies. There are many forms in which herbs can be administered. Anacardium occidentale is a plant with several benefits. The aim of this work is to Evaluate the effect of Anacardium occidentale cashew apple juice on kidney of Gentamicin Induced Injury in Albino Rats. Method: For this study, a total of thirty rats were employed. The positive control in Group 1 was given saline as usual. Groups 3, 4, and 5 each received 10, 20, and 40 ml/kg of the extract, whereas Group 2 received normal saline for eight days. Animals in groups 2 through 5 received gentamicin 100 mg/kg bw orally on the eighth (8th) day. On the ninth day, 20 hours after the previous dose, all animals were weighed once more and sacrificed using diethylether. Result: When compared to the paracetamol group, the extract significantly (P less than 0.05) raised RBC, PCV, Hb, platelet, and WBC values. When compared to the gentamicin group, there was no significant improvement in the weight to body size ratio of rats in the extracts group (P less than 0.05) when compared to the gentamicin group. The levels of urea were significantly improved (P less than 0.05) while creatinine level did not significantly reduce when compared to gentamicin group. Additionally, histological study supports biochemical parameters. Conclusion: The findings imply that Anacardium occidentale cashew apple may be useful in managing some renal disorders as well as protecting the kidney against some hazardous pollutants.