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Stereoselective Total Synthesis of Crassalactone A, a Natural Cytotoxic Styryl Lactone
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AbstractA stereoselective total synthesis of a naturally occurring cytotoxic styryl lactone, crassalactone A (1), has been accomplished. The synthesis involves (−)‐diisopropyl D‐tartrate as the starting material, and the stereoselective additions of Grignard reagent and MeNO2 to two chiral aldehyde intermediates as the key steps.
Title: Stereoselective Total Synthesis of Crassalactone A, a Natural Cytotoxic Styryl Lactone
Description:
AbstractA stereoselective total synthesis of a naturally occurring cytotoxic styryl lactone, crassalactone A (1), has been accomplished.
The synthesis involves (−)‐diisopropyl D‐tartrate as the starting material, and the stereoselective additions of Grignard reagent and MeNO2 to two chiral aldehyde intermediates as the key steps.
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