(176) IS HEMOGLOBIN A1C LEVEL A SIGNIFICANT PREDICTOR OF PENILE PROSTHESIS IMPLANTATION INFECTIONS?

Abstract Objectives Diabetes mellitus (DM) is a major risk factor for erectile dysfunction (ED). Penile prothesis implantation is a definitive treatment with good outcomes. However, postoperative infection remains a significant complication. This study investigates the association between Glycated Hemoglobin (HBA1c) levels and penile prosthesis infection rates. Methods This study is a multi-center retrospective study including all patients underwent penile prothesis implantation between 2015 and 2023. All procedures were performed by the same specialized surgeon. Preoperative, perioperative and postoperative care and prophylaxis were standardized for all patients. Results We retrieved and reviewed the records of 62 patients via patients electronic records. Mean age was 54.7±12.4, mean HBA1c was 6.8±1.5. Thirty-nine (62.9%) patients were diabetic. 56 (90.3%) implants were malleable, and 6 (9.6%) were inflatable devices. 11 (17.7%) patients developed penile prosthesis infection, with only 4 (6.4%) treated conservatively, whereas 7 (11.3%) patients required device removal. Patients who had implant infection had a significantly higher mean HbA1c level 8.4±1.9 vs 6.5±1.1 (P=0.002). Although mean HBA1c level was higher among patients who underwent device removal, it was not statistically significant (8.1± 2.2 vs. 6.7±1.3, P=0.093). Moreover, prosthesis infection patients were younger compared to those without prosthesis infection (45.9 ± 13.3 vs. 56.7 ± 11.5 years p=0.0113). DM, peyronie's disease, prosthesis type, operative time and smoking were not significantly associated with infection rate. On multivariate analysis, both higher HBA1c levels and young age were statistically significant predictors for post penile prosthesis infection. Conclusions High HBA1c level is associated with increased risk of infection after penile prosthesis implantation. Conflicts of Interest The authors have no conflict of interest to declare.