(245) FLACCID PENILE COLOUR-DOPPLER ULTRASOUND REPRESENTS A BETTER MARKER OF SYSTEMIC CARDIOVASCULAR STATUS THAN CAROTID COLOUR-DOPPLER ULTRASOUND

Abstract Objectives To assess the correlations between flaccid penile colour-Doppler ultrasound (fPCDU) parameters, carotid colour-Doppler ultrasound (CCDU) parameters and history of major adverse cardiovascular events (MACE) in men with erectile dysfunction (ED). Methods A consecutive series of 269 men (55.3±11.6 years) complaining of ED were evaluated with fPCDU (assessing cavernosal artery peak systolic velocity [CAPSV] and acceleration [CAA]) and CCDU (evaluating intima-media thickness [IMT], the presence of atherosclerotic plaques [AP] at the origin of the internal carotid artery [ICA], and the ratio between ICA-PSV and common carotid artery-PSV [ICA/CCA-PSV ratio], the latter widely used to extimate hemodynamic abnormalities at the ICA level). In addition, the history of MACE of the patients was collected. Results At fPCDU, the mean CAPSV was 13.9±4.2 cm/s, the mean CAA was 1.92±0.66 m/s2. At CCDU, the mean IMT was 0.8±0.3 cm/s, 37% of men had ICA-AP and the median ICA/CCA-PSV ratio was 0.7 [0.6-0.8]. Overall, 7.9% of men had a history of MACE (3.7% acute myocardial infarction, 2.4% NSTEMI, 0.7% stroke, 1.1% peripheral arterial thrombosis). At fPCDU, mean CAPSV was positively associated with mean CAA (p<0.0001). At CCDU, mean IMT was positively associated with mean ICA/CCA-PSV ratio (p<0.001). Both mean CAPSV and CAA were negatively associated with mean IMT and ICA/CCA-PSV ratio, respectively (all p < 0.001). Men with ICA-AP showed lower CAPSV and CAA than those without (both p <0.001). Men with a history of MACE showed lower penile CAPSV and CAA (both p<0.05), but no difference in IMT, ICA-AP or ICA/CCA-PSV ratio compared to those without. Al data were confirmed after adjusting for age. Conclusions Although fPCDU and CCDU blood flow parameters are associated, subjects with MACE history show worse fPCDU, but not CCDU, blood flow parameters, than those without MACE history. Hence, fPCDU represent a better marker of a worse systemic cardiovascular status respect to CCDU. Conflicts of Interest No