Platelet-rich plasma therapy for thin endometrium

Introduction. Thin endometrium presents a significant challenge in reproductive medicine, as it is a key factor reducing the effectiveness of in vitro fertilization and embryo transfer programs. Its presence is often associated with low pregnancy rates. Current treatment methods demonstrate unstable efficacy and require improvement. Aim. This review aims to provide a comprehensive assessment of the therapeutic potential of platelet-rich plasma as an innovative approach to increasing endometrial thickness and improving reproductive outcomes in patients with thin endometrium. Materials and Methods. Recent scientific literature was analyzed in a systemic manner, dealing with the use of platelet- rich plasma for thin endometrium. The methods of platelet-rich plasma preparation, its administration protocols, and reported clinical outcomes were studied. Furthermore, possible mechanisms of platelet-rich plasma effect provided on endometrial regeneration were considered, including the activation of angiogenesis and stimulation of cell growth through the release of growth factors. Results and Discussion. According to research data, intrauterine infusion of platelet- rich plasma may contribute to an increase in endometrial thickness, as well as improve implantation and pregnancy rates in patients with resistant forms of thin endometrium. However, the lack of unified platelet-rich plasma preparation methods and differences in treatment protocols complicate the direct comparison of results between studies. Safety profile of platelet-rich plasma therapy is assessed as favorable, with a minimal number of reported adverse events. Conclusions. Platelet-rich plasma therapy is a promising method for endometrium restoration in cases of insufficient thickness. Implementing this approach into widespread clinical practice requires conducting randomized controlled trials and developing standardized protocols for the preparation and application of platelet-rich plasma.