Analysis of underlying disease and infection source with sepsis patients: A 10-year prospective study

Abstract Sepsis with high mortality in critically ill patients, although there are many methods for early identification of sepsis such as qSOFA and NEWS, which patients with underlying diseases or infection sites were more prone to sepsis with very little research, our objective to explore another way to the successful preventing sepsis. We collected 2789 sepsis patients who were diagnosed by positive blood culture from 2013 to 2023 in our hospital. The Sepsis incidence rate was 485.07/100 000 in hospitalization, males/females 1.85, there were 3088 pathogenic were isolated belonging to 165 species, E. coli was the most frequent agent 31.70% overall, followed by Klebsiella pneumoniae and S. aureus accounting for 14.33% and 11.26% respectively. We found cancers were the frequent underlying disease with sepsis accounting for 15.63% overall, followed by hematologic malignancy, uremia, gallstones, and cholecystitis, type 2 diabetes accounting for 14.49%,6.10%,5.81%, and 4.48% respectively. We found urinary tract infections (UTIs) were the first infection source accounting for 17.0% overall, followed by suppurative cholecystitis and cholangitis, pulmonary infection, and catheter-associated bloodstream infections (CABSIs) accounted for 12.7%,11.9%, and 11.0% respectively. The sepsis mortality was 32.27%, ICU, hematologic malignanc, cancers, candidemia, mixed infection, pulmonary infection, and abdominal sepsis being the main mortality risk factors. Those studies reveal sepsis was common with cancers and hematologic malignancy patients, infection sources were mainly UTIs, suppurative cholecystitis and cholangitis, pulmonary infection, and CABSIs, the mortality risk factors for BSIs were ICU, hematologic malignancy, cancers, and candidemia.