Abstract 11912: Temporal Trends in the Incidence of Non-Shockable In-Hospital Cardiac Arrest in Septic Patients

Background: Owing to increased awareness of the timely recognition and treatment of sepsis in the USA, sepsis care has improved over time with better outcomes. Hypothesis: We hypothesized that the incidence of non-shockable in-hospital cardiac arrest (IHCA) has also improved over time with improving sepsis care. Aims: The primary objective was to evaluate temporal trends of non-shockable IHCA in septic patients. The secondary objective was to evaluate these trends stratified by age, sex, and race. Methods: Using the National Inpatient Sample, we studied all adult patients hospitalized with sepsis from 2005 to 2019. We used multivariate logistic regression for trend analysis. Results: Of 26 million adult patients admitted with sepsis from 2005 to 2019 in the USA, with a mean age of 66 ±0.043 years, 50% were females. The mean age decreased from 68 years in 2005 to 65 years in 2019. The risk-adjusted rates of non-shockable IHCA in septic patients decreased from 2.4% in 2005 to 1.1% in 2019 (Figure 1, Panel A) after accounting for differences in age, sex, and comorbidity burden. The risk-adjusted rates were highest in the age group 45-64 and lowest in the oldest age group ≥85 years (Panel B). Furthermore, the sex-stratified analysis showed consistently higher rates of non-shockable IHCA in males than in females throughout our study (Panel C). Finally, the risk-adjusted rates of non-shockable IHCA were consistently highest in Black patients compared to other races throughout our study period (Panel D). Conclusions: The incidence of non-shockable IHCA in septic patients has significantly improved with increased awareness and improved care of sepsis. Initiatives like Surviving Sepsis Campaign need continued implementation in hospitals, with constant monitoring of compliance with these guidelines to further improve the incidence of non-shockable IHCA in septic patients.