Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Prenatal PTZ exposure alters the susceptibility to PTZ‐induced and nonconvulsive epilepsy in rats
View through CrossRef
AbstractThe effects of prenatal PTZ treatment on convulsive threshold for PTZ and spontaneously occurring spike‐wave discharages (SWD) were studied in WAG/Rij rats. Pregnant females were either repeatedly injected with PTZ (40 mg/kg i.p.) or saline. The offspring were divided into four groups that were challenged with PTZ at one of the following postnatal days (PD): 40‐th, 70‐th, 100‐th and 130‐th. The PTZ pre‐treated group had a higher PTZ seizure threshold than the control at PD 40, 100 and 130, not at PD 70: than the control group had a higher threshold. Next there was an age‐dependent decrease in seizure threshold and latency.EEG monitoring at the age of 110–140 days showed a lower number of SWD for WAG/Rij rats prenatally treated with PTZ than for the control group. These results demonstrate that prenatal PTZ treatment protects rats against PTZ‐induced seizures and SWD.
Title: Prenatal PTZ exposure alters the susceptibility to PTZ‐induced and nonconvulsive epilepsy in rats
Description:
AbstractThe effects of prenatal PTZ treatment on convulsive threshold for PTZ and spontaneously occurring spike‐wave discharages (SWD) were studied in WAG/Rij rats.
Pregnant females were either repeatedly injected with PTZ (40 mg/kg i.
p.
) or saline.
The offspring were divided into four groups that were challenged with PTZ at one of the following postnatal days (PD): 40‐th, 70‐th, 100‐th and 130‐th.
The PTZ pre‐treated group had a higher PTZ seizure threshold than the control at PD 40, 100 and 130, not at PD 70: than the control group had a higher threshold.
Next there was an age‐dependent decrease in seizure threshold and latency.
EEG monitoring at the age of 110–140 days showed a lower number of SWD for WAG/Rij rats prenatally treated with PTZ than for the control group.
These results demonstrate that prenatal PTZ treatment protects rats against PTZ‐induced seizures and SWD.
Related Results
Platform Session B: Clinical Neurophysiology/Clinical Epilepsy
3:00 p.m.–6:00 p.m.
Platform Session B: Clinical Neurophysiology/Clinical Epilepsy
3:00 p.m.–6:00 p.m.
1
Jose F.
Tellez‐Zenteno,
1
Scott B.
Patten, and
1
Samuel
Wiebe
...
Portrait of Epilepsy on the Canvas of Global Health
Portrait of Epilepsy on the Canvas of Global Health
Global, regional, and national burden of epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD Epilepsy Collabora...
Bombax costatum Pellegr. & Vuillet attenuates pentylenetetrazol-induced seizure and cognitive impairment in rats via inhibition of oxidative stress
Bombax costatum Pellegr. & Vuillet attenuates pentylenetetrazol-induced seizure and cognitive impairment in rats via inhibition of oxidative stress
Abstract
Objectives
Epilepsy is a neurological disorder resulting from excessive electrical discharge in the brain. Bombax costatum (BC) is an herb ...
Withdrawal from ingested diazepam produces a pentylenetetrazol‐like stimulus in rats
Withdrawal from ingested diazepam produces a pentylenetetrazol‐like stimulus in rats
AbstractAn interoceptive stimulus produced by withdrawal from chronic diazepam is similar to that produced by the anxiogenic drug pentylenetetrazol (PTZ). Because the PTZ stimulus ...
Maternal epileptic seizure induced by Pentylenetetrazol: Apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain
Maternal epileptic seizure induced by Pentylenetetrazol: Apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain
AbstractEpilepsy is a prominent sign of neurological dysfunction in children with various fetal and maternal deficiencies. However, the detailed mechanism and influences underlying...
Specific and Nonspecific Multiple Unit Activities during the Onset of Pentylenététrazol Seizures. III. Animals with Ablations of the Cerebral Cortex
Specific and Nonspecific Multiple Unit Activities during the Onset of Pentylenététrazol Seizures. III. Animals with Ablations of the Cerebral Cortex
Summary: The effects of cortical ablations on behavior, wakefulness‐sleep states, and PTZ‐induced seizures were studied in a group of cats. Animals were divided in two groups: gro...
Neuropathology in the North American sudden unexpected death in epilepsy registry
Neuropathology in the North American sudden unexpected death in epilepsy registry
Abstract
Sudden unexpected death in epilepsy is the leading category of epilepsy-related death and the underlying mechanisms are incompletely understood. Risk factor...
Neuroprotective Efficacy of Curcumin and Berberine With Gabapentin Pretreatment Against Chemically Induced Intractable Epilepsy in Albino Mice
Neuroprotective Efficacy of Curcumin and Berberine With Gabapentin Pretreatment Against Chemically Induced Intractable Epilepsy in Albino Mice
Background- Epilepsy is a chronic neurological disease characterized by recurrent seizure and a significant number of patients suffering from drug resistant (intractable) epilepsy ...