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Synthesis of some novel 7‐substituted quinolonecarboxylic acids via nitroso and nitrone cycloadditions
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Abstract1‐Ethyl‐6‐fluoro‐7‐hydroxylamino‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid 7 can be either oxidized to the corresponding nitroso intermediate 8 or converted to the methylene nitrone 9. Both intermediates form cycloaddition products with selected dienes and olefins respectively. Also, the preparation of 1‐ethyl‐6‐fluoro‐7‐(hexahydro‐2‐methyl‐5H‐pyrrolo[3,4‐d]isoxazol‐5‐yl)‐3‐quinolinecarboxylic acid 5 via a nitrone cycloaddition is presented.
Title: Synthesis of some novel 7‐substituted quinolonecarboxylic acids via nitroso and nitrone cycloadditions
Description:
Abstract1‐Ethyl‐6‐fluoro‐7‐hydroxylamino‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid 7 can be either oxidized to the corresponding nitroso intermediate 8 or converted to the methylene nitrone 9.
Both intermediates form cycloaddition products with selected dienes and olefins respectively.
Also, the preparation of 1‐ethyl‐6‐fluoro‐7‐(hexahydro‐2‐methyl‐5H‐pyrrolo[3,4‐d]isoxazol‐5‐yl)‐3‐quinolinecarboxylic acid 5 via a nitrone cycloaddition is presented.
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