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CD155-TIGIT Axis as a Therapeutic Target for Cancer Immunotherapy
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Abstract:
Immune checkpoint inhibitors (ICIs) have shown unprecedented efficacy in
treating many advanced cancers. Although FDA-approved ICIs have shown promising efficacy
in treating many advanced cancers, their application is greatly limited by the low
response rate, immune-related adverse events (irAE), and drug resistance. Developing
novel ICIs holds great promise to improve the survival and prognosis of advanced cancer
patients. T-Cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed
on T cells, natural killer (NK) cells, and T regulatory cells. Increasing reports
have shown that the disrupting CD155-TIGIT axis could activate the immune system and
restore antitumor immune response. This review briefly summarized the role of TIGIT in
tumor immune escape and targeting CD155-TIGIT axis drugs in preclinical and clinical
trials for cancer immunotherapy.
Title: CD155-TIGIT Axis as a Therapeutic Target for Cancer
Immunotherapy
Description:
Abstract:
Immune checkpoint inhibitors (ICIs) have shown unprecedented efficacy in
treating many advanced cancers.
Although FDA-approved ICIs have shown promising efficacy
in treating many advanced cancers, their application is greatly limited by the low
response rate, immune-related adverse events (irAE), and drug resistance.
Developing
novel ICIs holds great promise to improve the survival and prognosis of advanced cancer
patients.
T-Cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed
on T cells, natural killer (NK) cells, and T regulatory cells.
Increasing reports
have shown that the disrupting CD155-TIGIT axis could activate the immune system and
restore antitumor immune response.
This review briefly summarized the role of TIGIT in
tumor immune escape and targeting CD155-TIGIT axis drugs in preclinical and clinical
trials for cancer immunotherapy.
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