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Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
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The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of
Streptomyces avermitilis
. Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.
American Society for Microbiology
Title: Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
Description:
The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of
Streptomyces avermitilis
.
Four closely related major components and four homologous minor components were separated from the complex.
Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components.
A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.
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