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4‐Chloropyridine Hydrochloride
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image
[7379‐35‐3]
C
5
H
4
ClN·HCl
(MW 150.01)
InChI =
1S/C5H4ClN.ClH/c6‐5‐1‐3‐7‐4‐2‐5;/h1‐4H;1H
InChIKey =
XGAFCCUNHIMIRV‐UHFFFAOYSA‐N
(reagent is an HCl salt of 4‐chloropyridine, heterocyclic building block used in metal‐catalyzed cross‐coupling reactions, nucleophilic aromatic substitutions, and lithiations)
Alternative Name
: 4‐chloropyridinium chloride and
p
‐chloropyridine hydrochloride.
Physical Data
: mp 210 °C; flash point 198 °C – closed cup.
Form Supplied in
: beige‐yellow to white solid; widely available.
Solubility
: soluble in water.
Handling, Storage, and Precautions
: keep containers tightly closed in a dry, cool, and well‐ventilated place. Acute toxicity, oral (Category 4) H302, eye irritation (Category 2A) H319, and LD
50
oral (rat) 566 mg kg
−1
.
Preparative Methods
: the reagent is prepared by dehydroxy‐chlorination of 4‐pyridinol, deaminative chlorination or Sandmeyer chlorination of 4‐aminopyridine, and chlorination of pyridine
N
‐oxide.
Title: 4‐Chloropyridine Hydrochloride
Description:
image
[7379‐35‐3]
C
5
H
4
ClN·HCl
(MW 150.
01)
InChI =
1S/C5H4ClN.
ClH/c6‐5‐1‐3‐7‐4‐2‐5;/h1‐4H;1H
InChIKey =
XGAFCCUNHIMIRV‐UHFFFAOYSA‐N
(reagent is an HCl salt of 4‐chloropyridine, heterocyclic building block used in metal‐catalyzed cross‐coupling reactions, nucleophilic aromatic substitutions, and lithiations)
Alternative Name
: 4‐chloropyridinium chloride and
p
‐chloropyridine hydrochloride.
Physical Data
: mp 210 °C; flash point 198 °C – closed cup.
Form Supplied in
: beige‐yellow to white solid; widely available.
Solubility
: soluble in water.
Handling, Storage, and Precautions
: keep containers tightly closed in a dry, cool, and well‐ventilated place.
Acute toxicity, oral (Category 4) H302, eye irritation (Category 2A) H319, and LD
50
oral (rat) 566 mg kg
−1
.
Preparative Methods
: the reagent is prepared by dehydroxy‐chlorination of 4‐pyridinol, deaminative chlorination or Sandmeyer chlorination of 4‐aminopyridine, and chlorination of pyridine
N
‐oxide.
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