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In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH 2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci
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ABSTRACT
The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH
2
and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and
Rhodococcus equi
. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
American Society for Microbiology
Title: In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH
2
and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci
Description:
ABSTRACT
The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH
2
and Pal-Lys-Lys against gram-positive cocci were investigated.
Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and
Rhodococcus equi
.
A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin.
These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
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