Javascript must be enabled to continue!
The Common Cold and Influenza in Children: To Treat or Not to Treat?
View through CrossRef
The common cold, which is mostly caused by respiratory viruses and clinically represented by the symptoms of acute respiratory viral infections (ARVI) with mainly upper respiratory tract involvement, is an important problem in pediatric practice. Due to the high prevalence, socio-economic burden, and lack of effective prevention measures (except for influenza and, partially, RSV infection), ARVI require strong medical attention. The purpose of this descriptive literature review was to analyze the current practical approaches to the treatment of ARVI to facilitate the choice of therapy in routine practice. This descriptive overview includes information on the causative agents of ARVI. Special attention is paid to the role of interferon gamma as a cytokine with antiviral and immunomodulatory effects on the pathogenesis of ARVI. Modern approaches to the treatment of ARVI, including antiviral, pathogenesis-directed and symptomatic therapy are presented. The emphasis is on the use of antibody-based drugs in the immunoprophylaxis and immunotherapy of ARVI. The data presented in this review allow us to conclude that a modern, balanced and evidence-based approach to the choice of ARVI treatment in children should be used in clinical practice. The published results of clinical trials and systematic reviews with meta-analyses of ARVI in children allow us to conclude that it is possible and expedient to use broad-spectrum antiviral drugs in complex therapy. This approach can provide an adequate response of the child’s immune system to the virus without limiting the clinical possibilities of using only symptomatic therapy.
Title: The Common Cold and Influenza in Children: To Treat or Not to Treat?
Description:
The common cold, which is mostly caused by respiratory viruses and clinically represented by the symptoms of acute respiratory viral infections (ARVI) with mainly upper respiratory tract involvement, is an important problem in pediatric practice.
Due to the high prevalence, socio-economic burden, and lack of effective prevention measures (except for influenza and, partially, RSV infection), ARVI require strong medical attention.
The purpose of this descriptive literature review was to analyze the current practical approaches to the treatment of ARVI to facilitate the choice of therapy in routine practice.
This descriptive overview includes information on the causative agents of ARVI.
Special attention is paid to the role of interferon gamma as a cytokine with antiviral and immunomodulatory effects on the pathogenesis of ARVI.
Modern approaches to the treatment of ARVI, including antiviral, pathogenesis-directed and symptomatic therapy are presented.
The emphasis is on the use of antibody-based drugs in the immunoprophylaxis and immunotherapy of ARVI.
The data presented in this review allow us to conclude that a modern, balanced and evidence-based approach to the choice of ARVI treatment in children should be used in clinical practice.
The published results of clinical trials and systematic reviews with meta-analyses of ARVI in children allow us to conclude that it is possible and expedient to use broad-spectrum antiviral drugs in complex therapy.
This approach can provide an adequate response of the child’s immune system to the virus without limiting the clinical possibilities of using only symptomatic therapy.
Related Results
Correlation of Influenza Vaccination and Influenza Incidence on COVID-19 Severity and Other Perspectives
Correlation of Influenza Vaccination and Influenza Incidence on COVID-19 Severity and Other Perspectives
The pandemic of COVID-19 is evolving worldwide, and it is associated with high mortality and morbidity. There is a growing need to discuss the elements of a coordinated strategy to...
1395. Influenza B-Associated Pediatric Mortality in the US Between 2010 and 2019
1395. Influenza B-Associated Pediatric Mortality in the US Between 2010 and 2019
Abstract
Background
To assess the contribution of influenza B to mortality in the US pediatric population, we analyzed the propo...
A New Influenza-Tracking Smartphone App (Flu-Report) Based on a Self-Administered Questionnaire: Cross-Sectional Study (Preprint)
A New Influenza-Tracking Smartphone App (Flu-Report) Based on a Self-Administered Questionnaire: Cross-Sectional Study (Preprint)
BACKGROUND
Influenza infections can spread rapidly, and influenza outbreaks are a major public health concern worldwide. Early detection of signs of an infl...
U.S. utilization patterns of influenza antiviral medications during the 2009 H1N1 influenza pandemic
U.S. utilization patterns of influenza antiviral medications during the 2009 H1N1 influenza pandemic
Please cite this paper as: Borders‐Hemphill and Mosholder (2012) U.S. utilization patterns of influenza antiviral medications during the 2009 H1N1 influenza pandemic. Influenza and...
The Clinical Effectiveness and Tolerability of Oseltamivir in Unvaccinated against Influenza Pediatric Patients in Two In-fluenza seasons after the COVID-19 pandemic.The Impact of Comorbidities on Hospitalization for Influenza in Children.
The Clinical Effectiveness and Tolerability of Oseltamivir in Unvaccinated against Influenza Pediatric Patients in Two In-fluenza seasons after the COVID-19 pandemic.The Impact of Comorbidities on Hospitalization for Influenza in Children.
Antiviral therapy such as Oseltamivir has been recommended for hospitalized children with suspected and confirmed influenza for almost 20 years. The therapy is officially authorize...
Burden and seasonality of medically attended influenza like illness (ILI) in Ethiopia, 2012 to 2017
Burden and seasonality of medically attended influenza like illness (ILI) in Ethiopia, 2012 to 2017
Abstract
Background
The influenza virus spreads rapidly around the world in seasonal epidemics, resulting in significant morbidity and mortality. In...
Prevalence of Influenza Virus Type and Subtype at Siriraj Hospital, Bangkok, Thailand During 2013 - 2017
Prevalence of Influenza Virus Type and Subtype at Siriraj Hospital, Bangkok, Thailand During 2013 - 2017
Background: Influenza A (pandemic and seasonal H1/H3) and influenza B viruses were the predominant circulating seasonal influenza strains. Following its massive outbreak in 2009 gl...
Comparative characteristics of clinical, laboratory and instrumental indicators in children with seasonal influenza depending on the virus strain
Comparative characteristics of clinical, laboratory and instrumental indicators in children with seasonal influenza depending on the virus strain
Introduction. According to the literature, it is known that clinical signs and symptoms of influenza may differ depending on age, the state of the human immune system, the serot...

