GW24-e0988 A novel polymorphism of the CYP4F2 gene is associated with acute coronary syndrome

Objectives CYP4F2 is responsible for metabolising arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the regulation of cardiovascular homeostasis. The present study aims to evaluate the association between the CYP4F2 gene polymorphism andacute coronary syndrome (ACS). Methods Four CYP4F2 SNPs were genotyped (rs1558139, rs3093166, rs3093194, rs2108622) by the TaqMan® SNP Genotyping Assay in Real-Time PCR System. We examined the association between the four SNPs and ACS using a haplotype-based case-control study that included separate analysis of the two ethnic groups, one was Han population (326 ACS patients and 338 control subjects) and the other was Uygur population (265 ACS patients and 276 control subjects). Results GG + GA genotype carriers of SNP4 (rs2108622) were more frequent among ACS patients than among controls not only in the Han population (97% vs. 92%) but also in the Uygur population (94% vs. 88%). After adjustment of confounding factors such as hypertension, diabetes, smoking, body mass index, triglyceride, the odds ratio (OR) for GG + GA genotype carriers of the rs2108622 in ACS was 2.325 (95% confidence interval:1.067-5.067) in the Han population and 2.220 (95% CI: 1.060-4.649) in the Uygur population. For the Uygur population, the frequency of the A-G-G haplotype was significantly higher for ACS patients than for control subjects (p = 0.046) Conclusions The GG + GA genotype of the rs2108622 in CYP4F2 gene may be a genetic marker of ACS in the Han and Uygur population. The T-G-G haplotype might be a dangerous genetic marker for ACS in the Uygur population of China.