Antioxidant potential of resveratrol on plasmodium berghei-induced malaria in diabetic male Wistar rats

Abstract Objective The aim of this study was to elucidate the antioxidant and antimalarial effects of resveratrol in diabetes and malaria comorbidity. Methods 40 males Wistar rats were divided into 8 groups. Induction of diabetes was done in 7 of the groups with high-fat diet (HFD) and 20% fructose solution as drinking water for 8 weeks. Thereafter, the seven groups were injected with single streptozotocin (30 mg/kg) intraperitoneally. Inoculation of malaria was achieved by injecting 0.2 ml of Plasmodium bergheiparasite mixture into the rats intraperitoneally. Meaningful values were set at P < 0.05. Results There were augments in mean body weight across the groups from day 0-6 after inoculation (day of sacrifice), but it was significantly reduced when compared to the normal control. The blood glucose levels (BGL)of the resveratrol groups significantly decreased on day 6 after inoculation, when compared with vitamin C and diabetic controls. For the average infected erythrocytes, the diabetic control had the greater (P < 0.05) count, when compared across the groups. The resveratrol groups had significantly (P < 0.05) lower values compared to the diabetic control. superoxide dismutase and malondialdehyde levels were significantly (P < 0.05) reduced in resveratrol 50 mg/kg rats, related to diabetic controls. Although malondialdehyde concentrations was markedly higher in resveratrol 100 mg/kg. Serum plasmodium lactate dehydrogenase (pLDH) enzymes concentrations of resveratrol groups were reduced (P < 0.05) when related with the diabetic controls. Conclusion It was concluded that resveratrol reduced BGL and suppressed the proliferation of P. berghei parasites in diabetic Wistar rats. Resveratrol exerted some modulatory effects on the malondialdehyde and superoxide dismutase and ameliorated adverse effect of P. berghei-induced malaria in diabetic Wistar rats.