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Posttransfusion Hepatitis in Japan
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AbstractThe incidence of posttransfusion hepatitis and the rate of chronicity were investigated in a program devised at our hospital in December, 1982. Out of 2,596 blood recipients between January, 1982, and December, 1987, 451 (22.7%) developed posttransfusion hepatitis. Seventy‐seven patients out of 217 (35.3%) whose course was closely followed progressed to chronicity. The incidence of posttransfusion hepatitis increased with the volume of transfused blood without any evident limitation. Recipients of elevated‐ALT donor blood (> 26 Karmen units) were found to be more susceptible to posttransfusion hepatitis than those who had received only normal‐ALT donor blood. Packed red blood cells, whole blood and fresh whole blood were high‐risk components, and fresh frozen plasma a low‐risk component of blood. The carrier rate of non‐A, non‐B hepatitis agents in Japanese healthy blood donors was determined to be 1.2% using the Frost‐Reed model of infectious diseases. Anti‐hepatitis C virus was detected in 62% of the cases of posttransfusion hepatitis 1 year after transfusion.
Title: Posttransfusion Hepatitis in Japan
Description:
AbstractThe incidence of posttransfusion hepatitis and the rate of chronicity were investigated in a program devised at our hospital in December, 1982.
Out of 2,596 blood recipients between January, 1982, and December, 1987, 451 (22.
7%) developed posttransfusion hepatitis.
Seventy‐seven patients out of 217 (35.
3%) whose course was closely followed progressed to chronicity.
The incidence of posttransfusion hepatitis increased with the volume of transfused blood without any evident limitation.
Recipients of elevated‐ALT donor blood (> 26 Karmen units) were found to be more susceptible to posttransfusion hepatitis than those who had received only normal‐ALT donor blood.
Packed red blood cells, whole blood and fresh whole blood were high‐risk components, and fresh frozen plasma a low‐risk component of blood.
The carrier rate of non‐A, non‐B hepatitis agents in Japanese healthy blood donors was determined to be 1.
2% using the Frost‐Reed model of infectious diseases.
Anti‐hepatitis C virus was detected in 62% of the cases of posttransfusion hepatitis 1 year after transfusion.
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