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Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization
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ABSTRACT
Monascus
fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties. To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation. A mutant strain, C‐23, was obtained, and the addition of L‐arginine increased MK production by 97.3%, reaching 9.45 mg/g. Untargeted metabolomics revealed that L‐arginine reshaped metabolic pathways related to amino acids, cofactors, carbohydrates, and lipids, elucidating the mechanism behind MK overproduction. This work provides a strategic approach for developing high‐yielding
Monascus
strains and offers insights into the metabolic regulation of MK biosynthesis.
Title: Enhanced Monacolin K Production in
Monascus purpureus
Via Mutagenesis and Nitrogen Source Optimization
Description:
ABSTRACT
Monascus
fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties.
To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation.
A mutant strain, C‐23, was obtained, and the addition of L‐arginine increased MK production by 97.
3%, reaching 9.
45 mg/g.
Untargeted metabolomics revealed that L‐arginine reshaped metabolic pathways related to amino acids, cofactors, carbohydrates, and lipids, elucidating the mechanism behind MK overproduction.
This work provides a strategic approach for developing high‐yielding
Monascus
strains and offers insights into the metabolic regulation of MK biosynthesis.
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