Dermatology

Over the past 50 years, there have been great advances in our understanding of skin biology and the aetiopathogenesis of skin diseases, and in the development of treatments for these. Immunosuppression for use in cutaneous infection, the use of antibiotics and corticosteroids in the reduction of morbidities in skin conditions, and an increasing understanding of molecular pathways, among a range of other developments, have allowed for rapid progression in the treatment of dermatological conditions. Carefully designed studies have been vital in the development of treatment; however, clinical observation continues to have a role. The increasing number of therapeutic options for skin conditions brings with it a need for better evidence of relative efficacy, acceptability, and long-term safety. Moreover, there are still many skin conditions for which limited effective treatments are available such as vitiligo, hidradenitis suppurativa, and viral warts. This chapter highlights the evidence base for some major advances in dermatology.