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Inflammation
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Fournier’s gangrene (FG) defines a life-threatening necrotizing fasciitis of the external genitalia and perineum with a peak incidence at 50 years of age. It is associated with a mixed bacterial infection with Escherichia coli and Bacteroides spp. predominating. The diagnosis is made clinically with symptoms of skin necrosis, swelling, pain, crepitus, and feculent odour, and local and systemic signs of severe sepsis. Initial resuscitation with fluid replacement, oxygen therapy, and broad-spectrum empirical antibiotics should be rapidly followed by complete and aggressive surgical debridement with postoperative placement of an occlusive dressing. Urinary and faecal diversions are often required. Debridement should be repeated until all necrotic tissue has been excised, allowing later reconstruction. Early diagnosis and immediate therapy is crucial to improve survival in patients with FG.
Title: Inflammation
Description:
Fournier’s gangrene (FG) defines a life-threatening necrotizing fasciitis of the external genitalia and perineum with a peak incidence at 50 years of age.
It is associated with a mixed bacterial infection with Escherichia coli and Bacteroides spp.
predominating.
The diagnosis is made clinically with symptoms of skin necrosis, swelling, pain, crepitus, and feculent odour, and local and systemic signs of severe sepsis.
Initial resuscitation with fluid replacement, oxygen therapy, and broad-spectrum empirical antibiotics should be rapidly followed by complete and aggressive surgical debridement with postoperative placement of an occlusive dressing.
Urinary and faecal diversions are often required.
Debridement should be repeated until all necrotic tissue has been excised, allowing later reconstruction.
Early diagnosis and immediate therapy is crucial to improve survival in patients with FG.
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