Carbetocin vs Oxytocin in Decreasing Intraoperative Blood Loss in Women Undergoing Caesarean Section

Abstract Background Primary postpartum haemorrhage (PPH) is a major cause of maternal mortality, accounting for 6% of all cases worldwide. PPH is defined as blood loss of 500 mL or more in vaginal delivery, or 1000 mL or more in cesarean delivery; these conditions can occur within the first 24 hours after delivery (primary PPH) or between 24 hours and 6 weeks after delivery (secondary PPH). Objective To compare Carbetocin vs Oxytocin in decreasing intraoperative blood loss in women undergoing Caesarean section. Patients and Methods This was a randomized controlled clinical trial that was conducted in Ain Shams University Maternity Hospital (ASUMH) on Women undergoing Ceaserean section attending Ain Shams Maternity Hospital. Results Need for other uterotonics & Incidence of PPH were higher in intervention (A) who received oxytocin compared to intervention (B) who received carbetocin with P value (<0,001&<0,001). There was no statistically significant difference between the two interventions as regards Hb drop and total estimated blood loss. Conclusion The current study showed that the use of Carbetocin and oxytocin were safe and effective in decreasing intra and postoperative blood loss in women undergoing planned cesarean section. The use of Carbetocin resulted in significantly decrease the need for other uterotonics & decrease risk of PPH compared to oxytocin alone.