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Chiral Separation of Diastereoisomers of Cefuroxime Axetil by High-Performance Thin-Layer Chromatography
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Abstract
Conditions for separation and determination of diastereoisomers of cefuroxime axetil by HPTLC on cellulose layers with densitometry were developed. A good separation of the constituents was achieved using a mobile phase composed of 1 aqueous -cyclodextrinmethanol (15 + 1, v/v). For detecting spots on the chromatograms, densitometric measurements were used at 285 nm. The method is characterized by high sensitivity; the LOD was 0.04 g/spot and LOQ was 0.11 g/spot for both forms of the cefuroxime axetil diastereoisomers. For the individual diastereoisomers, high recovery values from 96.63 to 104.16 were obtained. Identification of the diastereoisomers was performed by 1H-NMR spectrometric analysis.
Title: Chiral Separation of Diastereoisomers of Cefuroxime Axetil by High-Performance Thin-Layer Chromatography
Description:
Abstract
Conditions for separation and determination of diastereoisomers of cefuroxime axetil by HPTLC on cellulose layers with densitometry were developed.
A good separation of the constituents was achieved using a mobile phase composed of 1 aqueous -cyclodextrinmethanol (15 + 1, v/v).
For detecting spots on the chromatograms, densitometric measurements were used at 285 nm.
The method is characterized by high sensitivity; the LOD was 0.
04 g/spot and LOQ was 0.
11 g/spot for both forms of the cefuroxime axetil diastereoisomers.
For the individual diastereoisomers, high recovery values from 96.
63 to 104.
16 were obtained.
Identification of the diastereoisomers was performed by 1H-NMR spectrometric analysis.
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