Evaluation of anti-hyperlipidemic activity of Euphorbia Hirta bark against triton ® WR 1339 induced hyperlipidemia

Hyperlipidemia is the major risk factor causing many cardiovascular disorders like myocardial infarction and stroke, atherosclerosis. The world has complimented many herbal substances of therapeutic importance. There are many reports about the use of herbal medicine for reduction of lipid profile and reducing the cardiovascular risk in clinical subjects and experimental pharmacology. The plant Euphorbia hirta bark was evaluated for anti-hyperlipidemic activity by Triton (Superinone, Triton WR-1339), induced hyperlipidemia in rats. This study was carried out on the action of Euphorbia hirtabarkethanolic extracts, a known anti-hyperlipidemic drug, Simvostatin (10 mg/kg body wt.), was taken as a standard drug. The statistical parameters of mean± S.E were employed for the calculation of one way analysis of variance test (ANOVA) and Dunnet’s test for many comparison’s P < 0.05 were considered as significant. The studies were shown. There was a significant (P<0.01) reduction in serum levels in lipid profile experiments. It has reported a significant lower total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and an increase in high density lipoprotein (HDL).The study confirmed that ethanolic extract of Euphorbia hirta bark having significant anti-hyperlipidemic action proving a potential herbal medicine as an alternative to currenttreatment of hyperlipidemia.