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Solid‐Phase Synthesis of Oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage
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AbstractOligonuclecotides bearing phosphoramidate internucleotide linkages can be prepared chemically by standard solid‐phase DNA synthesis. Thus, phosphoramidate internucleotide bonds can be placed at will into specific positions within a given DNA fragment. The backbone‐modified DNA fragments prepared in this way are susceptible to a specific chemical cleavage.
Title: Solid‐Phase Synthesis of Oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage
Description:
AbstractOligonuclecotides bearing phosphoramidate internucleotide linkages can be prepared chemically by standard solid‐phase DNA synthesis.
Thus, phosphoramidate internucleotide bonds can be placed at will into specific positions within a given DNA fragment.
The backbone‐modified DNA fragments prepared in this way are susceptible to a specific chemical cleavage.
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