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Ca2+‐ and Mg2+‐Modulated Lipolysis in Neonatal Rat Brain Slices Observed by One‐ and Two‐Dimensional NMR
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Abstract: Superfused cortical brain slices from neonatal rats demonstrated large increases in levels of NMR‐detectable lipids after sample preparation and perfusion with standard artificial CSF. These increases were reduced by an average of 58% by perfusion with buffer with low (no added) Ca2+ or by perfusion in Ca2+‐free buffer. Perfusion with buffer with elevated MgSO4 (10 mmol/L) reduced the lipid changes by 47%. A reduction of 88% was observed in samples perfused in buffer with both low Ca2+ and high Mg2+, suggesting a role for Mg2+ in reducing lipolysis distinct from its known ability to block Ca2+ influx.
Title: Ca2+‐ and Mg2+‐Modulated Lipolysis in Neonatal Rat Brain Slices Observed by One‐ and Two‐Dimensional NMR
Description:
Abstract: Superfused cortical brain slices from neonatal rats demonstrated large increases in levels of NMR‐detectable lipids after sample preparation and perfusion with standard artificial CSF.
These increases were reduced by an average of 58% by perfusion with buffer with low (no added) Ca2+ or by perfusion in Ca2+‐free buffer.
Perfusion with buffer with elevated MgSO4 (10 mmol/L) reduced the lipid changes by 47%.
A reduction of 88% was observed in samples perfused in buffer with both low Ca2+ and high Mg2+, suggesting a role for Mg2+ in reducing lipolysis distinct from its known ability to block Ca2+ influx.
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