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Four New Tirucallane Triterpenoids from the Leaves of Ailanthus Triphysa with Anti‐Inflammatory Activities
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AbstractIsolation and determination of three new compounds from the leaves of Ailanthus triphysa (Dennst.) Alston with their anti‐inflammatory activity. Ten tirucallane triterpenes (1–10) including four undescribed compounds, ailantriphysas A–D (1–4), were isolated from the leaves of Ailanthus triphysa (Dennst.) Alston. Their structures were elucidated using IR, HR‐ESI‐MS, 1D‐ and 2D‐NMR spectra. Compound 1 inhibited lipopolysaccharide(LPS)‐induced nitric oxide production in RAW 264.7 cells with an IC50 value of 8.1±μM. Additionally, compound 1 also displayed significant inhibitory effects on the secretion of IL‐6 and TNF‐α at tested concentrations of 4, 8, and 16 μM.
Title: Four New Tirucallane Triterpenoids from the Leaves of Ailanthus Triphysa with Anti‐Inflammatory Activities
Description:
AbstractIsolation and determination of three new compounds from the leaves of Ailanthus triphysa (Dennst.
) Alston with their anti‐inflammatory activity.
Ten tirucallane triterpenes (1–10) including four undescribed compounds, ailantriphysas A–D (1–4), were isolated from the leaves of Ailanthus triphysa (Dennst.
) Alston.
Their structures were elucidated using IR, HR‐ESI‐MS, 1D‐ and 2D‐NMR spectra.
Compound 1 inhibited lipopolysaccharide(LPS)‐induced nitric oxide production in RAW 264.
7 cells with an IC50 value of 8.
1±μM.
Additionally, compound 1 also displayed significant inhibitory effects on the secretion of IL‐6 and TNF‐α at tested concentrations of 4, 8, and 16 μM.
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