Healing Effects of Juglans regia and Chamomile on Peptic Ulcer Therapy: Insights from Molecular Docking and Preclinical Studies

SUMMARY Introduction: Peptic ulcers are a common gastrointestinal disease affecting approximately 9 million people worldwide. Many drugs are effective in the treatment of this disease, but most of these drugs have harmful effects on other organs of the body. Herbal medicines have less harmful effects. Therefore, the aim of this study is to investigate the simultaneous extract of Juglans and chamomile on gastric ulcers. Materials and methods: In this study, 35 rats were used in 5 groups.: Control group, Peptic ulcer group, Peptic group and recipient of Juglans regia extract, Peptic group and recipient of chamomile extract, Peptic ulcer group and recipient of green Juglans regia + chamomile extract. Results: The results showed that Juglans regia extract + chamomile extract simultaneously restored the submucosal layer of the stomach, on the other hand, the results of hydroxyproline showed that The hydroxyproline content was significantly reduced in the peptic ulcer group, but in the group receiving the extract, the hydroxyproline content increased slightly. The ulcer group showed a significant difference compared to the other groups (p<0/5). The control group also showed a significant difference to the other groups (p<0/5). No significant difference was found between the groups receiving the extract. Discussion: The presence of a mixture of phytochemicals is the most important feature of plant extracts that exhibit versatile properties. Due to the complex nature of wound healing and the involvement of various components and processes, the integration of different plant extracts in a formulation is a new approach in wound healing