GW24-e3725 Tp-Te interval in Patients with Acute Hemorrhagic Stroke

Objectives To compare Tp-Te interval and Tp-Te/√R-R in patients with acute hemorrhagic stroke and healthy controls, examine the relationship of the parameters with mortality, and study the effect of hemorrhagic location on Tp-Te interval, Tp-Te/√R-R. Methods The 12-lead synchronisation electrocardiogram of 103 consecutive patients with acute hemorrhagic stroke and 100 healthy subjeccts were recorded. The Tp-Te interval in leads V2∼V4 were measured and corrected by Tp-Te/√R-R with the Bazett formula. The average of Tp-Te interval in leads V2∼V4 and that of Tp-Te/√R-R were calculated. The parameters were compared between the patients and the healthy controls. The patients were subdivided into the survivor and the death groups. The Tp-Te interval and Tp-Te/√R-R were compared between the two groups. The Tp-Te interval and Tp-Te/√R-R in the patients with different hemorrhagic locations (lobes, basal ganglia, brainstem and subarachnoid cavity) were also studied. Results The Tp-Te interval and Tp-Te/√R-R in patients with acute hemorrhagic stroke were longer than that in the healthy controls (104.60 ± 12.94ms vs 90.96 ± 7.67ms, t = 9.292, P<0.001; 122.60 ± 18.41ms vs 102.65 ± 10.30ms, t = 8.713, P<0.001), the differences were statistically significant. The Tp-Te interval and Tp-Te/√R-R in the death group were longer than that in the survivor group (110.13 ± 15.70ms vs 102.83 ± 11.48ms, t = 2.522, P = 0.001; 133.45 ± 23.67ms vs 119.12 ± 14.97ms, t = 3.587, P = 0.013), the differences were statistically significant. The Tp-Te interval and Tp-Te/√R-R in patients with different hemorrhagic locations (lobes, basal ganglia, brainstem and subarachnoid cavity) were different, the differences were statistically significant. ( F = 8.732, P<0.001; F = 5.831, P = 0.001; F = 3.789, P = 0.013; F = 3.313, P = 0.023). The parameters in patients with brainstem haemorrhage were the longest. The differences of the parameters in the other three groups were not statistically significant. Conclusions The dispersion of ventricular repolarisation and the transmural dispersion of repolarisation in patients with acute hemorrhagic stroke are greater than that in healthy subjects. Brainstem hemorrhage has the largest influence on the dispersion of ventricular repolarisation and the transmural dispersion of ventricular repolarisation compared with hemorrhage in other brain parts. The patients with brainstem hemorrhage are more susceptible to malignant arrhythmia and sudden cardiac death. The Tp-Te interval and Tp-Te/√R-R are new indexes to predict recent mortality in patients with acute hemorrhagic stroke.