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What impact does tautomerism have on drug properties and development?
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This mini-review reports on effects that tautomerism has on predicted and clinically observed small-molecule properties important for drug design and drug behaviour in the patient. We present examples of both pharmacokinetics and pharmacodynamics effects. The importance of tautomerism on drugs’ formulation and possible interconversion of stereoisomers is also discussed.
Title: What impact does tautomerism have on drug properties and development?
Description:
This mini-review reports on effects that tautomerism has on predicted and clinically observed small-molecule properties important for drug design and drug behaviour in the patient.
We present examples of both pharmacokinetics and pharmacodynamics effects.
The importance of tautomerism on drugs’ formulation and possible interconversion of stereoisomers is also discussed.
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