Nephroprotective activity of Albizia lebbeck pods in wistar albino rats by gentamicin induced nephrotoxicity

Background: In the Indian medicinal system, Albizia lebbeck is known for its various therapeutic properties, including antiseptic, anti-dysenteric, anti-tubercular, anti-asthmatic, and anti-fertility effects, which have been historically linked to it. Objective: The objective of the present study was to evaluate the ethanolic extract of Albizia lebbeck pods (ALPE) for its protective effects against gentamicin-induced nephrotoxicity in rats. Materials and Methods: The rats were divided into five groups: one receiving normal saline, another receiving gentamicin at 100 mg/kg i.p., a third group treated with Cystone at 5 ml/kg p. o. for 8 days, and two groups receiving ALPE at doses of 200 mg/kg and 400 mg/kg p. o. for 21 days, alongside gentamicin for 8 days. Serum levels of protein, creatinine, urea, and blood urea nitrogen were measured. After treatment, kidneys were collected for histological analysis. Results: The gentamicin treatment led to nephrotoxicity, evidenced by significant changes in blood parameters. However, the concurrent administration of the ethanolic extract of Albizia lebbeck pods with gentamicin markedly improved all measured parameters. Histopathological examinations indicated a decrease in kidney damage when treated with the extract. Conclusion: The results suggest that the ethanolic extract of Albizia lebbeck pods may be effective in preventing gentamicin-induced nephrotoxicity.