Privacy-Preserving Machine Learning in Healthcare Applications

The integration of machine learning (ML) in healthcare has unlocked transformative potential in disease prediction, personalized treatment, medical imaging, remote patient monitoring, and genomic data analysis. However, the sensitive nature of medical data introduces critical concerns regarding patient privacy, data security, and regulatory compliance. This chapter presents a comprehensive overview of privacy-preserving machine learning approaches tailored for healthcare applications, with a focus on technical frameworks, real-time implementations, and regulatory alignment. It explores the use of advanced techniques such as federated learning, differential privacy, homomorphic encryption, and zero-knowledge proofs to safeguard patient information while maintaining model utility. The chapter also addresses domain-specific challenges in processing real-time health data streams and implementing privacy-aware algorithms in resource-constrained environments. By bridging the gap between technical innovation and clinical applicability, this work emphasizes the importance of secure, scalable, and ethically aligned ML solutions in modern healthcare ecosystems. The discussion was contextualized within current legal frameworks and highlights future directions for research and implementation to ensure trust, transparency, and resilience in data-driven medical systems.