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Fractalkine Receptor/Ligand Genetic Variants and Carotid Intima-Media Thickness
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Background and Purpose—
The fractalkine ligand/receptor (CX3CL1/CX3CR1) complex is important in inflammatory responses and has been associated with vascular disease. We determined whether genetic variants in
CX3CL1
and
CX3CR1
are associated with carotid atherosclerosis in 2 large European populations.
Methods—
18 polymorphisms in
CX3CL1
and
CX3CR1
were genotyped in 2763 German community individuals (CAPS). Positive results were tested for replication on 6049 French community individuals (3C Study).
Results—
In CAPS we found associations of common carotid artery (CCA)-IMT with 2
CX3CL1
(rs170364, rs614230) and 1
CX3CR1
(rs3732378) variants, and significant interactions of
CX3CR1
rs11129820, rs3732378, and rs614230 variants with smoking and alcohol consumption in relation with CCA-IMT. None of these were replicated in 3C. In 3C only there was a borderline significant association of rs3732378 with carotid plaques.
Conclusion—
In almost 9000 subjects, we found no replicable associations of
CX3CL1
and
CX3CR1
polymorphisms with CCA-IMT or plaque.
Ovid Technologies (Wolters Kluwer Health)
Title: Fractalkine Receptor/Ligand Genetic Variants and Carotid Intima-Media Thickness
Description:
Background and Purpose—
The fractalkine ligand/receptor (CX3CL1/CX3CR1) complex is important in inflammatory responses and has been associated with vascular disease.
We determined whether genetic variants in
CX3CL1
and
CX3CR1
are associated with carotid atherosclerosis in 2 large European populations.
Methods—
18 polymorphisms in
CX3CL1
and
CX3CR1
were genotyped in 2763 German community individuals (CAPS).
Positive results were tested for replication on 6049 French community individuals (3C Study).
Results—
In CAPS we found associations of common carotid artery (CCA)-IMT with 2
CX3CL1
(rs170364, rs614230) and 1
CX3CR1
(rs3732378) variants, and significant interactions of
CX3CR1
rs11129820, rs3732378, and rs614230 variants with smoking and alcohol consumption in relation with CCA-IMT.
None of these were replicated in 3C.
In 3C only there was a borderline significant association of rs3732378 with carotid plaques.
Conclusion—
In almost 9000 subjects, we found no replicable associations of
CX3CL1
and
CX3CR1
polymorphisms with CCA-IMT or plaque.
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