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2.6.3 Epoxide Hydrolysis
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AbstractThis chapter focuses on the selective biocatalytic ring opening of epoxides by water, leading to vicinal diols or other reaction products. This strategy is also used by nature to prepare a range of important metabolites and natural products by epoxide hydrolase catalyzed ring-opening reactions. The hydrolysis of easily accessible racemic epoxides to enantiomerically pure epoxides or vicinal diols has become of increasing interest as a method for preparing a great variety of chiral intermediates for the synthesis of pharmacologically active compounds, agrochemicals, flavors and fragrances, and metabolites.
Title: 2.6.3 Epoxide Hydrolysis
Description:
AbstractThis chapter focuses on the selective biocatalytic ring opening of epoxides by water, leading to vicinal diols or other reaction products.
This strategy is also used by nature to prepare a range of important metabolites and natural products by epoxide hydrolase catalyzed ring-opening reactions.
The hydrolysis of easily accessible racemic epoxides to enantiomerically pure epoxides or vicinal diols has become of increasing interest as a method for preparing a great variety of chiral intermediates for the synthesis of pharmacologically active compounds, agrochemicals, flavors and fragrances, and metabolites.
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