ACUTE AND SUB-ACUTE TOXICITY STUDIES OF STARCH GLUTAMATE - A NOVEL SUPERDISINTEGRANT

Starch glutamate was a novel superdisintegrant which was synthesized from the native potato starch and glutamic acid by esterification process. The prepared starch glutamate toxicity was evaluated by performing acute and sub-acute toxicity studies on the Wister rats and Swiss albino mice. Acute toxicity studies were conducted on the Swiss albino mice by dividing them randomly into 10 groups (6 rats in each group) and treated with starch glutamate up to the concentration of 2000mg/Kg body weight, and then they were closely observed for 12 hrs for any toxic symptoms. Sub –acute toxicity studies were performed on the Wister rats by dividing them into 5 groups (6 rats in each group) and treating them with starch glutamate up to the concentration of 2000mg/Kg body weight once daily for 28 days and on 29th day animals were sacrificed and blood samples were analysed for change in haematological parameters and biochemical parameters. The prepared starch glutamate was safe up to the concentration of 2000mg/Kg body weight and it did not exhibit any change in the haematological parameters and bio-chemical parameters.