Processes of Lipid Peroxidation, Antioxidant Protection and Membrane Destruction of Renal Epithelium in the Pathogenesis of Dysmetabolic Nephropathy in Children

It should be noted that oxidative stress, as a universal mechanism of tissue hypoxia at the cellular level, accompanied by non-enzymatic free radical oxidation and accumulation of lipid peroxidation products (LPO) in the blood, has attracted particular interest among medical professionals in our time. Research in the last decade has shown that there are all reasons to consider the activation of free radical LPO as a nonspecific component of physiological and pathological reactions characterizing the stress of activation of homeostasis maintenance systems. The aim of stady to establish the relationship between the impact of LPO processes, antioxidant defense, and membrane destruction of renal epithelium in children with dysmetabolic nephropathy. Materials and methods. Two groups of examined children were formed from the examined group, including those with dysmetabolic nephropathy and secondary urinary tract infections: Group I - 52 individuals in whom dysmetabolic nephropathy was complicated by the superimposition of inflammatory processes in the kidneys and urinary tract - complicated DN (I-UDN), and Group II - 56 children with uncomplicated course of DN (II-DN), (a total of 108 children). The control group consisted of 65 healthy children. In children of all groups, the indicator of LPO process activity and the indicator of catalase activity in blood and urine were determined as a mechanism for regulating the antioxidant system of the body. Results. Against the intensification of lipid peroxidation and membrane destruction processes in the bodies of children with DN, the possibilities of antioxidant protection are exhausted, which, in turn, leads to even greater intensity of the LPO process. The catalase activity indicator in urine is an informative, reliable, and sensitive marker not only for the result of the impact of epigenetic factors on a child's body but also a prognostic marker for a more severe course of dysmetabolic nephropathy in children. Conclusions.The revealed facts allow us to assert that against the background of intensification of lipoperoxidation and membrane destruction processes in the body of children with DN, the possibilities of antioxidant protection are depleted, which in turn leads to an even greater intensity of the process of lipid peroxidation. And the index of catalase activity in urine is an informative, reliable and sensitive marker not only of the result of the impact of epigenetic factors on the child's body, but also a prognostic marker of a more severe course of dysmetabolic nephropathy in children.