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Rnf43
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RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. Loss of function of RNF43 results in decrease/lack of degradation of Frizzled with enhancement of Wnt/β-catenin signaling pathway. Mutations of RNF43 have been reported in different cancers. We describe the structure of RNF43, its function and most frequent mutations in different cancers.
Title: Rnf43
Description:
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway.
RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
Loss of function of RNF43 results in decrease/lack of degradation of Frizzled with enhancement of Wnt/β-catenin signaling pathway.
Mutations of RNF43 have been reported in different cancers.
We describe the structure of RNF43, its function and most frequent mutations in different cancers.
Related Results
Abstract 5839: Exome sequencing revealed comparable frequencies of RNF43 mutations and BRAF mutations in Middle Eastern colorectal cancer
Abstract 5839: Exome sequencing revealed comparable frequencies of RNF43 mutations and BRAF mutations in Middle Eastern colorectal cancer
Abstract
Mutation-induced activation of Wnt-β Catenin signaling is a frequent event in CRC. The E3 ubiquitin ligase, RNF43, has been reported to negatively regulate ...
The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity
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Abstract
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Abstract 1448: Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation
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A DNA repair player, ring finger protein 43, relieves etoposide‐induced topoisomerase II poisoning
A DNA repair player, ring finger protein 43, relieves etoposide‐induced topoisomerase II poisoning
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Abstract
Purpose
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Cover Image
Cover Image
imageOn the Cover: Model of Wnt/β‐catenin pathway in the presence and absence of Wnt ligand. This model illustrates the Wnt/β‐catenin pathway's activity in response to the presence...